Thionyl Chloride → 2-Methyl-6-(trifluoromethyl)nicotinoyl chloride

HRID 352453

반응식

HRID 352453 반응식
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:7]=1[C:8](O)=[O:9]>C1(C)C=CC=CC=1>[CH3:5][C:6]1[C:7]([C:8]([Cl:3])=[O:9])=[CH:11][CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27756832-Methyl-6-(trifluoromethyl)nicotinic acid

생성물 1

HCID 27756752-Methyl-6-(trifluoromethyl)nicotinoyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Thionyl chloride (4.35 g, 36.5 mmol) was added to a mixture of 2-methyl-6-trifluoromethyl nicotinic acid (5.00 g, 24.4 mmol) in 75 mL of toluene and the mixture was heated at reflux for 3 hours. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. Excess thionyl chloride was removed by azeotrope with toluene. The resultant acid chloride was used as is in Example 4, Step B.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3 hours
  3. customthe solvent was removed under reduced pressure
  4. customExcess thionyl chloride was removed by azeotrope with toluene

출처 및 근거

ORD 기록
ord-fcc309457f5246fa9eb719115ae465d7
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747047B2

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