4-Benzoylbenzoic acid → N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-4-benzoylbenzamide

HRID 352531

반응식

HRID 352531 반응식
[C:1]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[C:28]2[N:29]=[C:30]([CH2:37][CH2:38][CH2:39][CH3:40])[N:31]([CH2:32][CH2:33][CH2:34][CH2:35][NH2:36])[C:27]=2[C:26]2[N:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:20]=1>>[NH2:18][C:19]1[C:28]2[N:29]=[C:30]([CH2:37][CH2:38][CH2:39][CH3:40])[N:31]([CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:13](=[O:15])[C:12]3[CH:11]=[CH:10][C:9]([C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:17][CH:16]=3)[C:27]=2[C:26]2[N:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:20]=1

참가 물질

3

반응물 2

HCID 691474-Benzoylbenzoic acidHCID 129926164-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine

생성물 1

HCID 12018535N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-4-benzoylbenzamide수율 18%

실험 절차

Using the general method of Example 112 Part B, 4-benzoylbenzoic acid (72 mg, 0.32 mmole) was reacted with 4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butaneamine (100 mg, 0.32 mmol) to provide 30 mg of N1-[4-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyl]-4-benzoylbenzamide as a white solid. Mass-spec (M+1=521.31).

출처 및 근거

ORD 기록
ord-d98f49008ed44a2782e07dd3776b99fc
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747040B2

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