1H,3H-furo(3,4-c)pyridine-1,3-dione → N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide

HRID 352532

반응식

HRID 352532 반응식
[N:1]1[CH:6]=[CH:5][C:4]2[C:7]([O:9][C:10](=[O:11])[C:3]=2[CH:2]=1)=O.[F:12][C:13]([C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[C:24]([CH3:29])[CH:23]=1)([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15]>C1COCC1>[F:12][C:13]([C:22]1[CH:28]=[CH:27][C:25]([N:26]2[C:7](=[O:9])[C:4]3[CH:5]=[CH:6][N:1]=[CH:2][C:3]=3[C:10]2=[O:11])=[C:24]([CH3:29])[CH:23]=1)([C:18]([F:19])([F:20])[F:21])[C:14]([F:17])([F:16])[F:15]

참가 물질

4

반응물 2

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneHCID 99255434-(1,1,1,2,3,3,3-Heptafluoropropan-2-yl)-2-methylaniline

생성물 1

HCID 22712038N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In 10 ml of THF were dissolved 1.50 g of pyridine-3,4-dicarboxylic acid anhydride and 2.75 g of 4-(heptafluoro-2-propyl)-2-methylaniline, and the reaction was carried out at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and 20 ml of trifluoroacetic anhydride was added to the resulting residue, and the reaction was carried out with refluxing for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure to obtain crude N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide quantitatively.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure and 20 ml of trifluoroacetic anhydride
  3. additionwas added to the resulting residue
  4. temperaturewith refluxing for 3 hours
  5. customAfter completion of the reaction
  6. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-202579acd3bf46baa0df4b8eb4c95e2c
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747041B1

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