Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon Disulfide → 4-(Tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon Disulfide | HCID 6348 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Butanoic acid, 4-chloro-, methyl ester | HCID 76612 | — |
| 반응물 | Tetrahydrofurfurylamine | HCID 253298 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(Tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester | HCID 9903733 | — |
반응 단계
To a solution of tetrahydofurfurylamine (2 mL) in EtOH (20 mL) were added 5 N NaOH (3.9 mL) and carbon disulfide (1.17 mL), and the mixture was stirred for 1.5 h. Methyl 4-chlorobutyrate (2.4 mL) was then added, and the mixture was stirred overnight. Upon quenching with saturated NaCl solution the mixture was extracted with ether. Chromatography on silica gel gave the desired 4-(tetrahydrofuran-2-ylmethylthiocarbamoylsulfanyl)-butyric acid methyl ester product (1.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06747061B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-4bd9eb844c2a4b3f994ea8ed6e3ff0e7 |
| 출처 메모 | uspto-grants-2004_06 |