Tert-butyl 4-benzylpiperazine-1-carboxylate → 1-Benzylpiperazine hydrochloride

HRID 352777

반응식

[CH2:1]([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:21].C(O)C>>[ClH:21].[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 584330Tert-butyl 4-benzylpiperazine-1-carboxylate

HCID 21887872Ethanol hydrochloride

생성물 1

HCID 27566531-Benzylpiperazine hydrochloride수율 97%

실험 절차

To 1-benzyl-4-tert-butoxycarbonylpiperazine (3.12 g), saturated ethanol hydrochloride was added, followed by stirring for 90 minutes at room temperature. The solvent was distilled off under reduced pressure, followed by drying, whereby the title compound (2.73 g, 97%) was obtained as white powder.

후처리

distillationThe solvent was distilled off under reduced pressure
customby drying

출처 및 근거

ORD 기록: ord-33705c0319e7456583203d04feae1405
출처 데이터셋: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06747023B1

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