Hydrazine → 4,5-Dihydro-5-(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

HRID 3528

반응식

HRID 3528 반응식
[N+:1]([C:4]1[CH:24]=[CH:23][C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]3[CH:20]=[CH:21][CH:22]=[C:12]3[CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O.NN>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]3[CH:20]=[CH:21][CH:22]=[C:12]3[CH2:11]2)=[O:9])=[CH:23][CH:24]=1

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 218371354,5-Dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

생성물 1

HCID 218370054,5-Dihydro-5-(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 20 ml of ethyl alcohol is added 0.2 g of 10% Pd/C and 2.5 mmol of hydrazine followed by stirring and heating under reflux for 2 hours. The hot reaction mixture is filtered through diatomaceous earth and the filter cake washed with hot chloroform and the filtrate concentrated in vacuo. The residue is triturated with ethyl acetate and the mixture filtered to give the desired product as crystals, m.p. 225°-228° C.

후처리

  1. temperatureheating
  2. temperatureunder reflux for 2 hours
  3. filtrationThe hot reaction mixture is filtered through diatomaceous earth
  4. washthe filter cake washed with hot chloroform
  5. concentrationthe filtrate concentrated in vacuo
  6. customThe residue is triturated with ethyl acetate
  7. filtrationthe mixture filtered

출처 및 근거

ORD 기록
ord-f8a9d90712124232849f597147bf6228
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733905

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