Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → methyl 1H-benzimidazole-5-carboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 5-Benzimidazolecarboxylic acid | HCID 459456 | — |
| 생성물 | methyl 1H-benzimidazole-5-carboxylate hydrochloride | HCID 22710297 | 97% |
반응 단계
Under ice cooling, thionyl chloride (2.30 ml) was added dropwise to methanol (50 ml). Then, 5-benzimidazolecarboxylic acid (5.00 g) was added, followed by heating under reflux for 5 hours. The reaction mixture was distilled under reduced pressure. The residue was pulverized in diethyl ether, followed by collection through filtration, whereby colorless crystals (6.36 g, 97%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06747023B1 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-f89a7e124718480098b5995cbd3b23e9 |
| 출처 메모 | uspto-grants-2004_06 |