Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetylglycine → 2-Methyl-4-(3,5-dimethyl-4-(4-methoxy-3-(6-methoxy-3-pyridylmethyl)-phenoxy)-benzal)-5-oxazolone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetylglycine | HCID 10972 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 2-Methoxy-5-(2-methoxy-5-(2,6-dimethyl-4-formylphenoxy)benzyl)-pyridine | HCID 14673555 | — |
| 용매 | Acetic Anhydride | HCID 7918 | — |
| 생성물 | 2-Methyl-4-(3,5-dimethyl-4-(4-methoxy-3-(6-methoxy-3-pyridylmethyl)-phenoxy)-benzal)-5-oxazolone | HCID 54251361 | 64% |
반응 단계
2-Methoxy-5-(2-methoxy-5-(2,6-dimethyl-4-formylphenoxy)benzyl)-pyridine (10.84 g), N-acetylglycine (5.38 g), sodium acetate (3.77 g) and acetic anhydride (70 ml) were stirred at 100±5°, (oil bath temperature) for 24 hours. The solution was cooled and evaporated to leave a brown gum which was triturated with water, then with methanol to afford 2-methyl-4-(3,5-dimethyl-4-(4-methoxy-3-(6-methoxy-3-pyridylmethyl)-phenoxy)-benzal)-5-oxazolone as a yellow solid (8.27 g, 64%), m.p. 164°-165°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04766121 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-f276d13413624499a24384605d8576bb |
| 출처 메모 | uspto-grants-1988_08 |