Trifluoroacetic acid → HCID 69881589, 화합물

HRID 352974노트

반응식

HRID 352974 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>C(Cl)Cl>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([OH:35])=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86592091HCID 86592091, 화합물

생성물 1

HCID 69881589HCID 69881589, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In methylene chloride (1 ml) was dissolved tert-butyl [2-[[4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-6-yl)acetate (200 mg), followed by the addition of trifluoroacetic acid (2 ml). The resulting mixture was stirred at room temperature for 2 hours. After concentration under reduced pressure, diethyl ether was added to the residue. The precipitate so formed was collected by filtration, whereby the title compound (193 mg) was obtained as a colorless foam.

후처리

  1. concentrationAfter concentration under reduced pressure, diethyl ether
  2. additionwas added to the residue
  3. customThe precipitate so formed
  4. filtrationwas collected by filtration, whereby the title compound (193 mg)
  5. customwas obtained as a colorless foam

출처 및 근거

ORD 기록
ord-54e2a7f17c414988a04fec6518102959
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747023B1

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