Nitric Acid → 6-Nitrobenzothiazole

HRID 353018

반응식

HRID 353018 반응식
C[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[N+:11]([C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[CH:2][S:3][C:4]=2[CH:10]=1)([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 84462-Methylbenzothiazole2회

생성물 1

HCID 762566-Nitrobenzothiazole

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

See FIG. 3A. Nitration of 2-methylbenzothiazole was performed following the method of Mizuno, J. Pharm. Soc. Japan, 72, 745 (1952). A mixture of fuming nitric acid (1.6 mL) and concentrated sulfuric acid (1.2 mL) was added to an ice-cooled solution of 2-methylbenzothiazole (2 g) in sulfuric acid (8 mL). The solution was allowed to warm to room temperature for one hour, then poured onto 100 mL of ice. The solid was filtered, washed with water, and recrystallized from ethanol (80 mL) to provide 2.5 g of yellowish needles.

후처리

  1. filtrationThe solid was filtered
  2. washwashed with water
  3. customrecrystallized from ethanol (80 mL)

출처 및 근거

ORD 기록
ord-2ed0bbd2a51e40069fca902b09766555
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750024B2

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