Methanesulfonyl chloride → 4-Methanesulfonamidophthalimide

HRID 353046노트

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HRID 353046 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 729154-Aminophthalimide

생성물 1

HCID 9750204-Methanesulfonamidophthalimide수율 76.1%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulfonylchloride (2.6 ml, 0.034 mol) was added dropwise to a stirred suspension of 4-aminophthalimide (5.0 g, 0.031 mol) in pyridine (50 ml). The mixture was stirred for 48 h under N2 at room temperature, after which time the solid formed was isolated by filtration, washing well with H2O and CH2Cl2 and then dried in vacuo to afford the subtitle compound as a colourless solid (5.67 g, 76%). Rf 0.52 (CH2Cl2/MeOH/0.88NH3 90/10/1, v/v). MS m/z 241 (MH+).

후처리

  1. customafter which time the solid formed
  2. customwas isolated by filtration
  3. washwashing well with H2O and CH2Cl2
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-4d751eec7c3345618cadd334cf0e2e27
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750214B2

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