Phenyl isocyanate → 4-(6,7-Dimethoxy-4-quinazolinyl)-N-phenyl-1-piperazinecarboxamide

HRID 353126

반응식

HRID 353126 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[N:15]1[CH2:16][CH2:17][N:18]([C:28]([NH:27][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:29])[CH2:19][CH2:20]1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 27584846,7-Dimethoxy-4-piperazin-1-yl-quinazoline

생성물 1

HCID 110366394-(6,7-Dimethoxy-4-quinazolinyl)-N-phenyl-1-piperazinecarboxamide수율 44.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In 5 ml of ethanol was dissolved 278 mg (1.0 mmol) of 6,7-dimethoxy-4-piperazinylquinazoline obtained by the method described in South African Patent No. 67 06512 (1968), and 0.109 ml (1.0 mmol) of phenyl isocyanate was added thereto. The mixture was heated under reflux for 10 minutes and then allowed to cool to room temperature. The precipitated crystals were collected by filtration and recrystallized from ethanol to give 174.3 mg of the desired compound as colorless crystals. yield: 44%

후처리

  1. customobtained by the method
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for 10 minutes
  4. filtrationThe precipitated crystals were collected by filtration
  5. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-5ffd5bb6f69f4aa7829f9648c102a026
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750218B2

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