Water → 2-Amino-6-(2-furyl)-5-(4-propyl-3-pyridyl)-3-pyridinecarbonitrile

HRID 353230노트

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HRID 353230 반응식
[NH2:1][C:2]1[N:9]=[C:8]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)[C:7]([C:15]2[CH:20]=[CH:19][C:18](=O)[NH:17][CH:16]=2)=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:28](I)[CH2:29][CH3:30].O>CN(C)C=O>[NH2:1][C:2]1[C:3]([C:4]#[N:5])=[CH:6][C:7]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][C:20]=2[CH2:28][CH2:29][CH3:30])=[C:8]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 99654582-Amino-6-(2-furyl)-5-(6-oxo-1,6-dihydro-3-pyridinyl)nicotinonitrile

생성물 1

HCID 227080532-Amino-6-(2-furyl)-5-(4-propyl-3-pyridyl)-3-pyridinecarbonitrile수율 11.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
70 °C

실험 절차

2-Amino-6-(2-furyl)-5-(6-oxo-1,6-dihydro-3-pyridinyl)nicotinonitrile (20 mg, 0.072 mmol) and potassium carbonate (30 mg, 0.22 mmol) were introduced into a reaction vessel, dissolved in N,N-dimethylformamide (1 mL). Propyl iodide (52 mg, 0.31 mmol) was added thereto, followed by stirring at 70° C. for 18 hours. After the reaction was finished, water was added thereto, and it was extracted with ethyl acetate. After removing the aqueous layer, the organic layer was concentrated and purified by high performance liquid chromatography, to give the title product as a yellow solid (2.6 mg, 11%; 1.8 mg, 7.8%).

후처리

  1. extractionit was extracted with ethyl acetate
  2. customAfter removing the aqueous layer
  3. concentrationthe organic layer was concentrated
  4. custompurified by high performance liquid chromatography

출처 및 근거

ORD 기록
ord-de97b6d598a847c5be3c3f6f9ddab0ac
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750232B2

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