Potassium Carbonate → HCID 22485267, 화합물

HRID 353384노트

반응식

HRID 353384 반응식
Cl.COC1C=C(C=CC=1OC)OC1C=CC(S([C:17]2(C(NO)=O)CC[N:20](CC#C)[CH2:19][CH2:18]2)(=O)=O)=CC=1.C([O-])([O-])=O.[K+].[K+].CO[C:43]1[CH:44]=[C:45](O)[CH:46]=[CH:47][C:48]=1[O:49]C>CN(C)C=O>[O:49]([NH:20][CH2:19][C:18]#[CH:17])[C:48]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 162513,4-DimethoxyphenolHCID 1317238364-[[4-(3,4-dimethoxyphenoxy)phenyl] sulfonyl]-N-hydroxy-1-(2-propynyl)-4-piperidinecarboxamide, monohydrochloride

생성물 1

HCID 22485267HCID 22485267, 화합물수율 90.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Part C: To a solution of the propargyl amine of part B (8 g, 22.63 mmol) and powdered K2CO3 (8.8 g, 56.6 mmol) in N,N-dimethylformamide (150 mL) was added 3,4-dimethoxyphenol (6.98 g, 45 mmol) at ambient temperature. The composition was heated to 90 degrees Celsius for 36 hours. The solution was concentrated under high vacuum and the residue was dissolved in ethyl acetate. The organic layer was washed with 1N NaOH, H2O and dried over MgSO4. Chromatography (on silica, ethyl acetate/hexane) provided phenoxy propargyl amine as light yellow gel (10 g, 90.9%).

후처리

  1. temperatureThe composition was heated to 90 degrees Celsius for 36 hours
  2. concentrationThe solution was concentrated under high vacuum
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe organic layer was washed with 1N NaOH, H2O
  5. dry with materialdried over MgSO4

출처 및 근거

ORD 기록
ord-c4f247054abc48ff84edbe21d6b3c677
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06750233B2

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