Oxalyl chloride → N6-(Benzyloxycarbonyl)-9-(chlorocarbonylmethyl)adenine

HRID 353688노트

반응식

HRID 353688 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH2:7]([O:14][C:15]([NH:17][C:18]1[N:26]=[CH:25][N:24]=[C:23]2[C:19]=1[N:20]=[CH:21][N:22]2CC(O)=O)=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[CH2:7]([O:14][C:15]([NH:17][C:18]1[N:26]=[CH:25][N:24]=[C:23]2[C:19]=1[N:20]=[CH:21][N:22]2[CH2:1][C:2]([Cl:4])=[O:3])=[O:16])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 154805149H-Purine-9-acetic acid, 6-[[(phenylmethoxy)carbonyl]amino]-

생성물 1

HCID 22014446N6-(Benzyloxycarbonyl)-9-(chlorocarbonylmethyl)adenine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oxalyl chloride (6.3 g, 50 mmol) is added dropwise over 5 minutes to a solution of N6-(benzyloxycarbonyl)-9-(carboxymethyl)adenine (16.6 g, 50 mmol) dissolved in dichloromethane (200 mL). The reaction is stirred until gas evolution has ceased and then for an additional 2 hours. The reaction mixture is evaporated to an oil.

후처리

  1. customThe reaction mixture is evaporated to an oil

출처 및 근거

ORD 기록
ord-6ab82f6a965c4e4ebdab6ea898398bbd
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756199B1

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