Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
DL-Carnitine → Tert-butyl acetyl carnitine chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | DL-Carnitine | HCID 288 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | Tert-butyl acetyl carnitine chloride | HCID 131715696 | 80% |
반응 단계
Carnitine chloride (1.97 g; 0.01 moles) was dissolved in trifluoroacetic acid (10 cc). To the solution tert-butyl acetyl chloride (1.4 cc; 0.01 moles) was slowly added under stirring. The resulting mixture was kept under stirring at room temperature for 48 hours. To the mixture Et2O was added and the thus obtained precipitate was filtered off. The raw product was crystallized from isopropanol-ethyl ether, thus obtaining a pure product. MP 164°-165° C. Yield 80%
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04766222 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-02fba49a08984876a7c07be75ff83bf6 |
| 출처 메모 | uspto-grants-1988_08 |