DL-Carnitine → Tert-butyl acetyl carnitine chloride

HRID 35371

반응식

HRID 35371 반응식
[CH3:1][N+:2]([CH2:5][CH:6]([OH:11])[CH2:7][C:8]([O-:10])=[O:9])([CH3:4])[CH3:3].[C:12](CC([Cl:19])=O)([CH3:15])([CH3:14])[CH3:13].[CH3:20][CH2:21][O:22]CC>FC(F)(F)C(O)=O>[C:12]([CH:5]([N+:2]([CH3:3])([CH3:4])[CH3:1])[C:6]([C:21](=[O:22])[CH3:20])([CH2:7][C:8](=[O:10])[O-:9])[OH:11])([CH3:15])([CH3:14])[CH3:13].[Cl-:19]

참가 물질

5

반응물 3

HCID 288DL-CarnitineHCID 3283Diethyl EtherHCID 815143,3-Dimethylbutanoyl chloride

생성물 1

HCID 131715696Tert-butyl acetyl carnitine chloride수율 80%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Carnitine chloride (1.97 g; 0.01 moles) was dissolved in trifluoroacetic acid (10 cc). To the solution tert-butyl acetyl chloride (1.4 cc; 0.01 moles) was slowly added under stirring. The resulting mixture was kept under stirring at room temperature for 48 hours. To the mixture Et2O was added and the thus obtained precipitate was filtered off. The raw product was crystallized from isopropanol-ethyl ether, thus obtaining a pure product. MP 164°-165° C. Yield 80%

후처리

  1. stirringunder stirring at room temperature for 48 hours
  2. filtrationthe thus obtained precipitate was filtered off
  3. customThe raw product was crystallized from isopropanol-ethyl ether
  4. customthus obtaining a pure product

출처 및 근거

ORD 기록
ord-02fba49a08984876a7c07be75ff83bf6
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766222

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