1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 353718

반응식

HRID 353718 반응식
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

생성물 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one수율 63.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 1-acetyl-4-(4-nitrophenyl)piperazine (1.8 g, 7.2 mmol) (from Step A above) and 10% palladium-on-charcoal in ethanol (50 mL) was hydrogenated at room temperature and atmospheric pressure overnight. The catalyst was filtered off and the filter cake washed thoroughly with ethanol. The mixture was evaporated under reduced pressure to give 1-acetyl-4-(4-amino-phenyl)piperazine (1.0 g, 63%) as an off-white solid.

후처리

  1. customwas hydrogenated at room temperature
  2. customatmospheric pressure overnight
  3. filtrationThe catalyst was filtered off
  4. washthe filter cake washed thoroughly with ethanol
  5. customThe mixture was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-143dbfbc16664caf8759b3054bd49f39
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756374B2

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