Cyanamide → 3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile

HRID 353752

반응식

HRID 353752 반응식
[N:1]#[C:2][NH2:3].[N:4]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH:19]([CH3:21])[CH3:20])[CH2:15][CH2:14]2)=[CH:9][CH:8]=1)=[C:5]=[S:6].[C:22]([C:24]1[CH:25]=[C:26]([CH:31]=[CH:32][CH:33]=1)[C:27](=[O:30])[CH2:28]Br)#[N:23]>>[NH2:1][C:2]1[N:3]=[C:5]([NH:4][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH2:14][CH2:15][N:16]([CH:19]([CH3:21])[CH3:20])[CH2:17][CH2:18]3)=[CH:11][CH:12]=2)[S:6][C:28]=1[C:27]([C:26]1[CH:25]=[C:24]([CH:33]=[CH:32][CH:31]=1)[C:22]#[N:23])=[O:30]

참가 물질

4

반응물 3

HCID 9864CyanamideHCID 27358673-(2-Bromoacetyl)benzonitrileHCID 98783861-(4-Isothiocyanatophenyl)-4-(1-methylethyl)piperazine

생성물 1

HCID 219589073-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile

실험 절차

This compound was prepared from cyanamide, 1-(4-isothio-cyanatophenyl)-4-isopropypiperazine (of Example 3) and 3-cyanophenacyl bromide (Maybridge Chemical Co. Ltd.) following the procedure used in Example 24. Mass spectrum (ES) MH+=447.

출처 및 근거

ORD 기록
ord-748c19b58f914be88183d232a5126ad1
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756374B2

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