Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Iodo-1-tritylimidazole → 2-(1H-imidazol-4-yl)pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Iodo-1-tritylimidazole | HCID 618252 | — |
| 반응물 | 2-Bromopyrazine | HCID 642800 | — |
| 반응물 | HCID 178418443 | HCID 178418443 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 촉매 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(1H-imidazol-4-yl)pyrazine | HCID 178420761 | — |
반응 단계
To a solution of 4-Iodo-1-trityl-1H-imidazole (1 eq) in THF at room temperature was added ethylmagnesium bromide (1.2 eq) under dry conditions. After stirring for 90 minutes, zinc chloride (1.2 eq) was added to the reaction mixture. After stirring for another 90 minutes, tetrakis(triphenylphosphine) palladium (10%) and 5-bromopyrazine (1.3 eq) were added to the reaction mixture. Subsequent reaction conditions and work up are as described previously in Example 73, the resulting solid 2-(1H-Imidazol-4-yl)-pyrazine (37%) was collected by filtration. MH+(147).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06756359B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-2ffb63a6393a408bb6de2ae981e79900 |
| 출처 메모 | uspto-grants-2004_06 |