O-Phenylenediamine → ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate
반응식
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].Cl.C(O[C:13](=N)[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])C>CCO>[N:7]1[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[NH:8][C:13]=1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]참가 물질
4
실험 절차
A solution of 1,2-phenylenediamine (1.0 eq) and ethyl 3-ethoxy-3-iminopropanoate hydrochloride (1.3 eq) in EtOH was stirred at 90° C. overnight. The reaction was cooled to room temperature and the solvent removed in vacuo. Water and CH2Cl2 were added to the residue. The organic layer was separated, dried over Na2SO4 and the solvent removed. The solid recovered was used without purification. LC/MS m/z 205.2 (MH+), Rt 1.44 minutes.
후처리
- customthe solvent removed in vacuo
- additionWater and CH2Cl2 were added to the residue
- customThe organic layer was separated
- dry with materialdried over Na2SO4
- customthe solvent removed
- customThe solid recovered
- customwas used without purification
출처 및 근거
- ORD 기록
- ord-7ebd6310aecc423cba1434ab8eef2675
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06756383B2
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