Morpholine → 5-Morpholino-2-nitroaniline
반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CN1C(=O)CCC1.O>[N:12]1([C:2]2[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
5-Fluoro-2-nitrophenylamine (1.0 eq) and morpholine (3.0 eq) were dissolved in NMP and heated at 100° C. for 1 hour. The solution was cooled to room temperature and diluted with water. The resulting precipitate was filtered and dried under vacuum to yield 5-morpholin-4-yl-2-nitrophenylamine. The resulting solid was recrystallized from EtOH to afford pure product as a bright yellow solid. LC/MS m/z 224.1 (MH+), Rt 1.89 minutes.
후처리
- temperatureThe solution was cooled to room temperature
- filtrationThe resulting precipitate was filtered
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-091d127904f0438386f6af3233b66fb2
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06756383B2
반응 노트
불러오는 중…