ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate → HCID 178507209, 화합물

HRID 353803

반응식

HRID 353803 반응식
[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[NH:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=[C:12]1[CH2:20][C:21]([O:23]CC)=O.[NH2:26][C:27]1[NH:31][CH:30]=[N:29][C:28]=1[C:32]#[N:33]>C1COCC1>[NH2:33][C:32]1[C:28]2[N:29]=[CH:30][NH:31][C:27]=2[NH:26][C:21](=[O:23])[C:20]=1[C:12]1[NH:11][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:13]=1

참가 물질

5

반응물 3

HCID 308071ethyl 2-(1H-1,3-benzodiazol-2-yl)acetateHCID 2733832Lithium HexamethyldisilazideHCID 178510601HCID 178510601, 화합물

생성물 1

HCID 178507209HCID 178507209, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

LiHMDS (4.4 eq) was added to ethyl 1H-benzimidazol-2-ylacetate (1.0 eq) and 5-amino-1H-imidazole-4-carbonitrile (1.0 eq) in THF at 0° C. After 1 hour, the resulting mixture was warmed to room temperature and then stirred overnight. The mixture was quenched with an aqueous saturated NH4Cl solution and extracted with EtOAc. The organic layer was washed with H2O and brine, dried over Na2SO4, filtered, and concentrated in vacuo to yield a brown solid. LC/MS m/z 267.1 (MH+), Rt 1.47 minutes.

후처리

  1. customThe mixture was quenched with an aqueous saturated NH4Cl solution
  2. extractionextracted with EtOAc
  3. washThe organic layer was washed with H2O and brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customto yield a brown solid

출처 및 근거

ORD 기록
ord-211b82304f9c4f05bf68fa97f91a988a
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756383B2

연결된 노트

불러오는 중…