Oxalyl chloride → 4-(Chloromethyl)benzoyl chloride
반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][CH2:8][C:9]1[CH:17]=[CH:16]C(C(O)=O)=[CH:11][CH:10]=1>ClCCl.CN(C)C=O>[Cl:7][CH2:8][C:9]1[CH:17]=[CH:16][C:1]([C:2]([Cl:4])=[O:3])=[CH:11][CH:10]=1참가 물질
5
실험 절차
Oxalyl chloride (4.4 mL of 2M in chloroform, 8.8 mmol) was added to a suspension of 4-(chloromethyl)benzoic acid (1 g, 5.7 mmol) in dichloromethane. N,N-dimethylformamide (4 drops) was added to catalyze the reaction. After 1 hour analysis by HPLC indicated 100% clean conversion. The reaction mixture was concentrated under vacuum to provide 4-(chloromethyl)benzoyl chloride.
후처리
- customthe reaction
- concentrationThe reaction mixture was concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-7cadaf82a2f04fe683c43460d0dc3fad
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06756382B2
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