Cadaverine → N-(5-Aminopentyl)benzamide

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8](N)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

반응물 2

HCID 273Cadaverine

HCID 2331Benzamide

생성물 1

HCID 345353N-(5-Aminopentyl)benzamide수율 70.6%

실험 절차

Under an argon atmosphere, 1,5-diaminopentane (25 g, 0.24 mol) and benzamide (9.9 g, 0.081 mol) were combined and heated at reflux overnight. The reaction mixture was concentrated under vacuum to remove the excess diamine. The residue was distilled at about 210° C. at 12 torr (16×102 pascals) to provide 11.8 g of N-(5-aminopentyl)benzamide as a colorless oil.

후처리

temperatureheated
temperatureat reflux overnight
concentrationThe reaction mixture was concentrated under vacuum
customto remove the excess diamine
distillationThe residue was distilled at about 210° C. at 12 torr (16×102 pascals)

출처 및 근거

ORD 기록: ord-b381b192013040f686acf978ecc3b618
출처 데이터셋: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06756382B2

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