Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Silica | HCID 24261 | — |
| 반응물 | 1-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane | HCID 13827695 | — |
| 생성물 | Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate | HCID 13954659 | 92.8% |
반응 단계
In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol) and silicon dioxide (50.8 g, 0.85 mol) were charged, and concentrated sulfuric acid (60 g, 0.61 mol) was dropwise added thereto while stirring. The reaction was continued at 110° C. for 21 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (192.9 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04766238 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-988e1b0b73ce447b954125e277789977 |
| 출처 메모 | uspto-grants-1988_08 |