Water → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

HRID 35386

반응식

HRID 35386 반응식
[Cl:1][CH2:2][O:3][C:4](F)(F)[CH:5]([C:10]([F:13])([F:12])[F:11])[C:6]([F:9])([F:8])[F:7].O.S(=O)(=O)(O)[OH:18]>>[F:7][C:6]([F:9])([F:8])[CH:5]([C:10]([F:13])([F:12])[F:11])[C:4]([O:3][CH2:2][Cl:1])=[O:18]

참가 물질

4

반응물 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 138276951-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane

생성물 1

HCID 13954659Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate수율 101.1%

실험 절차

In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol) and water (18.7 g, 1.04 mol) were charged, and concentrated sulfuric acid (74.8 g, 0.76 mol) was dropwise added thereto while stirring The reaction was continued at 110° C. for 20 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (187.8 g).

후처리

  1. additionwere charged
  2. distillationThen, the reaction mixture was distilled

출처 및 근거

ORD 기록
ord-e4070553ddc946cb8b5dbbc6afa5647f
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766238

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