Triethylamine → 3,3,3-Trifluoro-2-(trifluoromethyl)-1-propene
반응식
C(N(CC)CC)C.[F:8][C:9]([F:21])([F:20])[CH:10]([C:16]([F:19])([F:18])[F:17])[C:11](OCCl)=O>>[F:8][C:9]([F:21])([F:20])[C:10]([C:16]([F:19])([F:18])[F:17])=[CH2:11]참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
In a four necked 100 ml flask equipped with a condenser, a dropping funnel and a thermometer, triethylamine (20.0 g, 198 mmol) was charged and warmed to 60° C. Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (4.88 g, 20 mmol) was dropwise added thereto while stirring. The reaction was continued at the same temperature as above for 2.5 hours while stirring. The gas evolved from a top of the condenser was washed with an alkaline solution, dried with alumina and cooled. The resultant liquid was distilled to give 2-trifluoromethyl3,3,3-trifluoropropene (2.36 g). Yield, 72 %.
후처리
- customIn a four necked 100 ml flask equipped with a condenser, a dropping funnel
- customwas continued at the same temperature as above for 2.5 hours
- stirringwhile stirring
- washwas washed with an alkaline solution
- customdried with alumina
- temperaturecooled
- distillationThe resultant liquid was distilled
출처 및 근거
- ORD 기록
- ord-782b180886ab49749e0f4174bf616e31
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04766238
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