홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methanol → Morpholine-4-carboxylic acid[1-(3-cyano-pyrrolidin-3-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide

HRID 353962
노트
인쇄 미리보기

반응식

HRID 353962 반응식
C(OC([N:11]1[CH2:15][CH2:14][C:13]([C:36]#[N:37])([NH:16][C:17](=[O:35])[CH:18]([NH:26][C:27]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:28])[CH2:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:12]1)=O)C1C=CC=CC=1.CO>CCO.C(Cl)Cl.[Pd]>[C:36]([C:13]1([NH:16][C:17]([CH:18]([NH:26][C:27]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:28])[CH2:19][CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]2)=[O:35])[CH2:14][CH2:15][NH:11][CH2:12]1)#[N:37]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 887MethanolHCID 22091411HCID 22091411, 화합물

생성물 1

HCID 22260517Morpholine-4-carboxylic acid[1-(3-cyano-pyrrolidin-3-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

3-Cyano-3-{3-cyclohexyl-2-[(morpholine-4-carbonyl)-amino]-propionylamino}-pyrrolidine-1-carboxylic acid benzyl ester (0.1 g, 0.20 mmol, 1.0 equiv) was dissolved in 15 mL of absolute EtOH. 10% Pd on carbon (20 mg) was added and the mixture was stirred under 1 atm of H2 until the starting material disappeared by TLC (5% MeOH in CH2Cl2. The crude mixture was filtered on diatomaceous earth and the filtrate was concentrated. The crude material was purified by reverse-phase HPLC to give two diastereomers; MS, m/z 378=M+1.

후처리

  1. filtrationThe crude mixture was filtered on diatomaceous earth
  2. concentrationthe filtrate was concentrated
  3. customThe crude material was purified by reverse-phase HPLC
  4. customto give two diastereomers

출처 및 근거

ORD 기록
ord-97cb7466e5c742acbbbd4f48c782c141
출처 데이터셋
uspto-grants-2004_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06756372B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트