Amlodipine Besylate → Amlodipine tetrahydro-5-oxo-2-furancarboxylate
반응식
[O:1]=[C:2]1[O:6][CH:5]([C:7]([O-:9])=[O:8])[CH2:4][CH2:3]1.[CH3:10][CH2:11][O:12][C:13]([C:15]1[CH:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=2[Cl:27])[C:19]([C:28]([O:30][CH3:31])=[O:29])=[C:18]([CH3:32])[NH:17][C:16]=1[CH2:33][O:34][CH2:35][CH2:36][NH2:37])=[O:14].C1C=CC(S(O)(=O)=O)=CC=1>O>[CH3:10][CH2:11][O:12][C:13]([C:15]1[CH:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=2[Cl:27])[C:19]([C:28]([O:30][CH3:31])=[O:29])=[C:18]([CH3:32])[NH:17][C:16]=1[CH2:33][O:34][CH2:35][CH2:36][NH2:37])=[O:14].[O:1]=[C:2]1[O:6][CH:5]([C:7]([O-:9])=[O:8])[CH2:4][CH2:3]1참가 물질
4
실험 절차
To investigate the stability in an aqueous state, mlodipine tetrahydro-5-oxo-2-furancarboxylate prepared in Example 3 and amlodipine besylate prepared in Reference Example 1 were separately dissolved in distilled water. The resulting aqueous solutions were stored at 25° C. for 4 weeks in the dark, after which a measurement was made of the contents of the salts with resort to HPLC under the same conditions as in the solid state.