Chlorosulfonic acid → 3-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride
반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
118 g (0.73 mole) of 5,6,7,8-tetrahydro-2-naphthol methyl ether are dissolved in 320 ml of methylene chloride, and 177 ml of chlorosulfonic acid in 160 ml of methylene chloride are added. The mixture is stirred for 10 minutes at 5° C. and is poured into ice water. The organic phase is separated off and dried with MgSO4. The solvent is removed by evaporation and the residue is recrystallized from acetone/petroleum ether.
후처리
- customThe organic phase is separated off
- dry with materialdried with MgSO4
- customThe solvent is removed by evaporation
- customthe residue is recrystallized from acetone/petroleum ether
출처 및 근거
- ORD 기록
- ord-7aed8e15419c45bdbbd0df5886e4abad
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04766241
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