Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 354023생성일: 2026년 10월 25일
Diisobutylaluminum hydride → (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
https://huagongshe.com/reaction/354023
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisobutylaluminum hydride | HCID 14487 | — |
| 반응물 | Ethyl 2-((tert-butoxycarbonyl)amino)-1,3-thiazole-4-carboxylate | HCID 22280595 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester | HCID 22280475 | — |
반응 단계
A solution of ethyl 2-[(N-Boc)amino]-4-thiazolecarboxylate (1 mmole) in CH2Cl2 (10 mL) was cooled to −78° C., and treated with DIBAL-H (1M, 5 ML). The reaction was stirred at −60° C. for 3 h, and quenched with a suspension of NaF/H2O (1 g/1 mL). The resulting mixture was filtered and the filtrate was concentrated to give 2-[(N-Boc)amino]-4-hydroxymethylthiazole as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06756360B1 |
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| 출처 데이터셋 | uspto-grants-2004_06 |
|---|
| ORD ID | ord-e54be4ccf6624a928e5630811ab220bd |
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| 출처 메모 | uspto-grants-2004_06 |
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