Selenium Dioxide → 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

HRID 354035노트

반응식

HRID 354035 반응식
[CH3:1][C:2]1[O:3][C:4](=[O:8])[O:5][C:6]=1[CH3:7].[Se](=O)=[O:10]>O1CCOCC1>[CH3:7][C:6]1[O:5][C:4](=[O:8])[O:3][C:2]=1[CH2:1][OH:10]

참가 물질

4

반응물 2

HCID 24007Selenium DioxideHCID 1422104,5-Dimethyl-1,3-dioxol-2-one

생성물 1

HCID 105108784-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 4,5-dimethyl-2-oxo-1,3-dioxolene (1 mmole) and selenium dioxide (2.5 mmole) in dioxane was heated at reflux for 1 h. Evaporation, extraction and chromatography gave 5-methyl-4-hydroxymethyl-2-oxo-1,3-dioxolene as a yellow oil. TLC: RPf=0.5, 5% MeOH-dichloromethane.

후처리

  1. temperatureat reflux for 1 h
  2. customEvaporation, extraction and chromatography

출처 및 근거

ORD 기록
ord-00ab9a8fb71941918916069b9a5c11f7
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756360B1

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