Potassium Hydroxide → 4-(2-Chloroethoxy)benzoic acid
반응식
C[C:2]1[CH:10]=[C:9]([O:11][CH2:12][CH2:13][Cl:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[K+]>CO>[Cl:14][CH2:13][CH2:12][O:11][C:9]1[CH:10]=[CH:2][C:3]([C:4]([OH:6])=[O:5])=[CH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To methyl 4-(2-Chloroethoxy)-benzoic acid (11.8 gm, 53.5 mmol) dissolved in 118 mL of methanol was added 2N KOH (35mL, 1.3 equiv.) and the resulting solution was heated at 50° C. for 24 hrs. The reaction was cooled to room temperature and the methanol evaporated off. The residue was diluted with water and extracted once with ethyl acetate. The aqueous layer was then acidified with 6N HCl and a precipitate formed which was filtered off, washed well with water, and pumped dry under vacuum to yield 10 gm of the title compound.
후처리
- temperatureThe reaction was cooled to room temperature
- customthe methanol evaporated off
- additionThe residue was diluted with water
- extractionextracted once with ethyl acetate
- customa precipitate formed which
- filtrationwas filtered off
- washwashed well with water
- custompumped dry under vacuum
출처 및 근거
- ORD 기록
- ord-d7372df631b542349a22e590570c18c4
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06756388B1
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