6-Methoxy-2-(1-cyclohexenyl)benzo[b]thiophene → 6-Methoxy-2-cyclohexylbenzo[b]thiophene
반응식
[C:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>[Pd].C(OCC)(=O)C>[CH:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=3[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1참가 물질
4
실험 절차
The product from Example 19, Step 1 (264 mg) and 10% Palladium on Carbon (60 mg) in 30 mL of ethyl acetate was added to a Parr shaker flask and hydrogenated at 50 psi for 16 hrs. at room temperature. The mixture was filtered over celite and concentrated. The crude product was chromatographed on silica gel using Hexanes as the eluant to give 210 mg of the title compound.
후처리
- customat room temperature
- filtrationThe mixture was filtered over celite and
- concentrationconcentrated
- customThe crude product was chromatographed on silica gel
출처 및 근거
- ORD 기록
- ord-2c077a95b394429ebdf2ebb1d871f618
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06756388B1
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