(1-Benzylpiperidin-2-yl)methanol → [4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone

HRID 354086노트

반응식

HRID 354086 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:28]=1.[CH2:29]([N:36]1[CH2:41][CH2:40][CH2:39][CH2:38][CH:37]1[CH2:42]O)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:29]([N:36]1[CH2:41][CH2:40][CH2:39][CH2:38][CH:37]1[CH2:42][O:19][C:16]1[CH:15]=[CH:14][C:13]([C:11]([C:10]2[C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:28][C:7]=3[S:8][C:9]=2[C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)=[O:12])=[CH:18][CH:17]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

참가 물질

3

반응물 2

HCID 2735486(1-Benzylpiperidin-2-yl)methanolHCID 98651972-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene

생성물 1

HCID 23512907[4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone수율 36%

실험 절차

The product from Step 2 (600 mg) was coupled with (1-benzyl-piperidin-2-yl)-methanol (379 mg) as is Example 10, Step 3 to yield the title compound (320 mg) after silica gel chromatography with 10% ethyl acetate/hexanes to 20% ethyl acetate/hexanes as the gradient eluant.

출처 및 근거

ORD 기록
ord-9b2015e6bfd948daacd0faf5365a3720
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756388B1

반응 노트

불러오는 중…