Ammonia → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

HRID 35414

반응식

HRID 35414 반응식
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](Cl)(=[O:18])=[O:17])[C:8]=1[OH:20])=[O:4].[NH3:21]>CC(C)=O.O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](=[O:18])(=[O:17])[NH2:21])[C:8]=1[OH:20])=[O:4]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

생성물 1

HCID 132103556-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

33.8 g (0.1 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane are dissolved in a little acetone, and the solution is added dropwise to 50 ml of concentrated ammonia solution. The mixture is stirred for 30 minutes at room temperature and is diluted with water. The precipitate which is deposited is filtered off with suction and dissolved in acetone, and the solution is filtered and stirred into water again.

후처리

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. dissolutiondissolved in acetone
  3. filtrationthe solution is filtered
  4. stirringstirred into water again

출처 및 근거

ORD 기록
ord-d94f91d0f9144c46a22b824f9bf58f64
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766241

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