1-Methylimidazole → N3-[2-(2-nitrophenyl)propoxycarbonyl]-N-methyl imidazolium chloride

HRID 354211노트

반응식

HRID 354211 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([CH3:16])[CH2:11][O:12][C:13]([Cl:15])=[O:14])([O-:3])=[O:2].[CH3:17][N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1>ClCCl>[Cl-:15].[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH:10]([CH3:16])[CH2:11][O:12][C:13]([N:20]1[CH:21]=[CH:22][N+:18]([CH3:17])=[CH:19]1)=[O:14])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 13901-MethylimidazoleHCID 114479052-(2-Nitrophenyl)propyl chloroformate

생성물 1

HCID 11232610N3-[2-(2-nitrophenyl)propoxycarbonyl]-N-methyl imidazolium chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.07 ml 2-(2-nitrophenyl)propoxycarbonyl chloride (1) (4.4 mmol) are slowly added dropwise to a solution of 1.24 ml N-methylimidazole (14.7 mmol) in 40 ml dichloromethane at 0° C. over molecular sieve 4 Å. Following stirring for 30 minutes in an ice bath this solution is used directly for acylation with 1.2 equivalents of the 5′-O-protected nucleoside building blocks.

출처 및 근거

ORD 기록
ord-1487ffc257de4f5f9cb5e2ac9376ae8f
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06756492B1

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