Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexane → Boc-L-Pro-Ome
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 용매 | Benzene methanol | HCID 21927730 | — |
| 생성물 | Boc-L-Pro-Ome | HCID 1277666 | 100% |
반응 단계
To a stirred solution of the N-tert-butoxycarbonylproline (6.00 g, 0.0279 mol) in MeOH:benzene (1:4, v/v) was added dropwise 2.0 M-n-hexane solution of TMSCHN2 (16.7 mL, 0.0334 mol) at room temp. After the resulting solution was stirred for 1 hr at room temp, the mixture was evaporated off in vacuo to afford 6.39 g (100%) N-tert-butoxycarbonylproline methyl ester as a yellow syrup. 1H-NMR (CDCl3) δ1.41 (s, 9H), 1.85-1.98 (m, 4H), 2.21-2.28 (m, 2H), 3.72 (s, 3H), 4.29 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06756378B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-9b482ae4f8e2409bab4080ac4c46c3e6 |
| 출처 메모 | uspto-grants-2004_06 |