Ethyl Acetate → 2,2,5,5-Tetramethylcyclopentan-1-ol

HRID 35435

반응식

HRID 35435 반응식
[CH3:1][C:2]1([CH3:10])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[C:3]1=[O:9].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)(=O)C>O1CCCC1>[CH3:1][C:2]1([CH3:10])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[OH:9]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 1382872,2,5,5,-TetramethylcyclopentanoneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 5516962,2,5,5-Tetramethylcyclopentan-1-ol수율 81.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a magnetically stirred solution of 10 g (0.071 mol) 2,2,5,5-tetramethylcyclopentanone in 75 ml of dry tetrahydrofuran at 0° C. under argon is added 2.69 g (0.071 mol) of lithium aluminum hydride. When the reduction was complete, ethyl acetate was introduced dropwise to destroy unreacted lithium aluminum hydride. 25 mls of water is then added, followed by 300 mls of diethyl ether. The organic phase is washed with 100 mls of water, and dried over MgSO4. Filtration followed by evaporation afforded 8.23 g of 2,2,5,5-tetramethylcyclopentanol.

후처리

  1. customto destroy unreacted lithium aluminum hydride
  2. addition25 mls of water is then added
  3. washThe organic phase is washed with 100 mls of water
  4. dry with materialdried over MgSO4
  5. filtrationFiltration
  6. customfollowed by evaporation

출처 및 근거

ORD 기록
ord-bdca90d81c604ce08ab4d87250b6bdb7
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766246

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