Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Cyclohexadiene → 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Cyclohexadiene | HCID 12343 | — |
| 반응물 | N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 53791828 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester | HCID 17992581 | — |
반응 단계
N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester is dissolved in absolute alcohol at 0° C. in an ultrasound bath. Palladium on carbon (10%) is added. The hydrogen source, 1,4-cyclohexadiene, is added, and ultrasound is commenced for eight minutes. The slurry is then filtered through a bed of Celite with ethyl alcohol. The solvent is removed by rotary evaporation to yield 1-aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04766246 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-53af94323f0249e79cb917e1a1115caf |
| 출처 메모 | uspto-grants-1988_08 |