1,4-Cyclohexadiene → 1-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester

HRID 35439

반응식

HRID 35439 반응식
[CH3:1][C:2]1([CH3:26])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[O:9][C:10]([C:12]1([NH:15]C(OCC2C=CC=CC=2)=O)[CH2:14][CH2:13]1)=[O:11].[H][H].C1CC=CCC=1>[Pd]>[CH3:7][C:4]1([CH3:8])[CH2:5][CH2:6][C:2]([CH3:1])([CH3:26])[CH:3]1[O:9][C:10]([C:12]1([NH2:15])[CH2:14][CH2:13]1)=[O:11]

참가 물질

5

반응물 3

HCID 123431,4-CyclohexadieneHCID 53791828N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 179925811-Aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester is dissolved in absolute alcohol at 0° C. in an ultrasound bath. Palladium on carbon (10%) is added. The hydrogen source, 1,4-cyclohexadiene, is added, and ultrasound is commenced for eight minutes. The slurry is then filtered through a bed of Celite with ethyl alcohol. The solvent is removed by rotary evaporation to yield 1-aminocyclopropylcarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester.

후처리

  1. filtrationThe slurry is then filtered through a bed of Celite with ethyl alcohol
  2. customThe solvent is removed by rotary evaporation

출처 및 근거

ORD 기록
ord-53af94323f0249e79cb917e1a1115caf
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766246

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