Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → Ethyl 2,6-dimethyl-3-(propan-2-yl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 3-Methylbutanal | HCID 11552 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | ethyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate | HCID 76918 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 2,6-dimethyl-3-(propan-2-yl)benzoate | HCID 13126300 | 8.3% |
반응 단계
Morpholine (13.34 g), isovaleraldehyde (13.18 g), p-toluenesulfonic acid (0.2 g), and toluene (300 ml) were combined and heated at reflux using a Soxhlet extractor with magnesium sulfate to remove any water produced. After three hours the Soxhlet extractor was replaced with a condenser, and ethyl 4,6-dimethyl-2-oxo-2H-pyran-5-carboxylate (30 g) was added. The reaction mixture was heated under reflux for approximately 64 hours. The solvent was evaporated, and the resultant oil was distilled to give 11.1 g of crude product which was chromatographed to yield ethyl 2,6-dimethyl-3-(1-methylethyl)benzoate (2.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04375476 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-3deaa738e08b489ea56184426ebd4810 |
| 출처 메모 | uspto-grants-1983_03 |