Ethanol → Ethyl 3-amino-4,4-difluorobutanoate hydrochloride
반응식
[F:1][CH:2]([F:9])[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[NH2:4].S(Cl)([Cl:12])=O.[CH2:14](O)[CH3:15]>ClCCl>[ClH:12].[CH2:14]([O:7][C:6](=[O:8])[CH2:5][CH:3]([NH2:4])[CH:2]([F:9])[F:1])[CH3:15]참가 물질
5
반응 조건
- 온도
- 25 °C
실험 절차
A solution of 2 mmole of beta-difluoromethyl beta-alanine in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour and concentrated to afford 3-amino-3-difluoromethylpropionic acid ethyl ester hydrochloride.
후처리
- additionis added
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-9cef3e6946324cbabd35f3ba3eb8b3be
- 출처 데이터셋
- uspto-grants-1983_03
- 특허 번호
- US04375477
반응 노트
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