Sodium Carbonate → 4-tert-butyl-2,3-dimethylpyridine N-oxide

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[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=1[CH3:12])([CH3:4])([CH3:3])[CH3:2].ClC1C=CC=C(C(OO)=[O:21])C=1.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][N+:8]([O-:21])=[C:7]([CH3:11])[C:6]=1[CH3:12])([CH3:4])([CH3:3])[CH3:2]

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실험 절차

A solution of 10.5 g of 4-tert-butyl-2,3-dimethylpyridine in 120 ml of methylene chloride is treated at room temperature with 14.4 g of m-chloroperbenzoic acid. The reaction mixture is made basic with a saturated sodium carbonate solution and extracted. The organic solution is dried and concentrated. The residue is purified on a silica qel column, whereby the medium pressure flash chromatography method (solvent: methylene chloride/ethyl acetate, with increasing ethyl acetate concentrations) is used and the pressure is produced with nitrogen gas. The 4-tert-butyl-2,3-dimethylpyridine N-oxide obtained is processed directly.