1-Chloro-4-(4-chlorophenyl)butan-2-ol → 1-Chloro-4-(4-chlorophenyl)butan-2-one

HRID 354589노트

반응식

HRID 354589 반응식
[Cl:1][CH2:2][CH:3]([OH:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O.O>[Cl:1][CH2:2][C:3](=[O:13])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1

참가 물질

5

반응물 2

HCID 124320331-Chloro-4-(4-chlorophenyl)butan-2-olHCID 131709961Jones' reagent

생성물 1

HCID 128164651-Chloro-4-(4-chlorophenyl)butan-2-one수율 97.7%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

A solution of 1-chloro-4-(4-chlorophenyl)-2-butanol (125 g) in acetone (200 ml) at 0° C. was treated with 570 ml of Jones reagent (from sodium dichromate dihydrate (100 g), concentrated sulfuric acid (136 g) and water to 500 ml) and stirred overnight at room temperature. The resulting solution was diluted with water (200 ml), extracted with ether (3×300 ml) and the extracts washed with water, aqueous sodium bicarbonate, and dried (MgSO4). Evaporation of the ether gave 121 g of 1-chloro-4-(4-chlorophenyl)-2-butanone. The analytical sample from hexane had m.p. 65°-67° C.

후처리

  1. extractionextracted with ether (3×300 ml)
  2. washthe extracts washed with water, aqueous sodium bicarbonate
  3. dry with materialdried (MgSO4)
  4. customEvaporation of the ether

출처 및 근거

ORD 기록
ord-864bb812126e4cc4b9f770d7b72f7ab3
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04375474

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