1,4-Dibromo-2-butyne → 1-(4-Bromo-2-butyn-1-yl)-5, 6-dichloro-3-ethyl-2-methylbenzimidazolium bromide

HRID 354592

반응식

HRID 354592 반응식
[Cl:1][C:2]1[C:13]([Cl:14])=[CH:12][C:5]2[N:6]([CH2:10][CH3:11])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.[Br:15][CH2:16][C:17]#[C:18][CH2:19]Br>CCOCC>[Br-:15].[Br:15][CH2:16][C:17]#[C:18][CH2:19][N+:8]1[C:4]2[CH:3]=[C:2]([Cl:1])[C:13]([Cl:14])=[CH:12][C:5]=2[N:6]([CH2:10][CH3:11])[C:7]=1[CH3:9]

참가 물질

4

반응물 2

HCID 752051,4-Dibromo-2-butyneHCID 767171H-Benzimidazole, 5,6-dichloro-1-ethyl-2-methyl-

생성물 1

HCID 867388101-(4-Bromo-2-butyn-1-yl)-5, 6-dichloro-3-ethyl-2-methylbenzimidazolium bromide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

5,6-Dichloro-1-ethyl-2-methylbenzimidazole (11.5 g., 0.05 moles) and 1,4-dibromo-2-butyne (31 g., 0.15 moles) were mixed together and stirred at room temperature overnight. The reaction mixture was treated with ether, the solid was collected by filtration, washed with ether and dried. It was recrystallized from acetonitrile containing 5% water (400 ml). The product was recovered in two crops. Yield 20.2 g (92%), mp. 185°-189° C.

후처리

  1. filtrationthe solid was collected by filtration
  2. washwashed with ether
  3. customdried
  4. customIt was recrystallized from acetonitrile containing 5% water (400 ml)
  5. customThe product was recovered in two crops

출처 및 근거

ORD 기록
ord-2a5f7d380d3e4f4693277dabeadcca5f
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04375508

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