Dichloromethane → 2-Chloro-N-pyridin-2-yl-acetamide

HRID 354640

반응식

HRID 354640 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(Cl)Cl.[Cl:11][CH2:12][C:13](Cl)=[O:14]>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:13](=[O:14])[CH2:12][Cl:11]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 104392-Aminopyridine

생성물 1

HCID 2894352-Chloro-N-pyridin-2-yl-acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 9.42 g. (0.1 mole) of 2-aminopyridine in 50 ml. of methylene chloride was added dropwise 4.0 ml. (0.05 mole) of chloroacetyl chloride in 20 ml. of the same solvent, keeping the reaction temperature at -20° to -10° C. for one hour. After stirring at room temperature for 10 hours, 50 ml. of water was added and the organic layer separated. The organic solution was washed with water and a brine solution and was dried over magnesium sulfate. Removal of the solvent in vacuo gave 6.64 g. (78%), m.p. 114°-117° C., of the desired product.

후처리

  1. customat -20° to -10° C.
  2. customfor one hour
  3. customthe organic layer separated
  4. washThe organic solution was washed with water
  5. dry with materiala brine solution and was dried over magnesium sulfate
  6. customRemoval of the solvent in vacuo
  7. customgave 6.64 g

출처 및 근거

ORD 기록
ord-c8118f53ef5d431aaa4f72d8f69651ac
출처 데이터셋
uspto-grants-1983_03
특허 번호
US04376204

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