2,3-Dimethyl-4-nitropyridine-N-oxide → Pyridine, 4-methoxy-2,3-dimethyl-, 1-oxide

HRID 35465

반응식

HRID 35465 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([N+]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:12].[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:6]1[CH:5]=[CH:4][N+:3]([O-:12])=[C:2]([CH3:1])[C:7]=1[CH3:8]

참가 물질

4

반응물 2

HCID 1482232,3-Dimethyl-4-nitropyridine-N-oxideHCID 10942334Sodium Methoxide

생성물 1

HCID 10630707Pyridine, 4-methoxy-2,3-dimethyl-, 1-oxide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2.5 g (0.015 mol) of 2,3-dimethyl-4-nitropyridine 1-oxide in 50 ml of abs. methanol is treated with 0.883 g of sodium methylate, whereupon the mixture is stirred at room temperature under argon for 2 days. The reaction mixture is concentrated and the residue is extracted with methylene chloride and saturated sodium chloride solution. The methylene chloride phase is dried and evaporated. The residue, crystallized from methylene chloride/ ether, gives 4-methoxy-2,3-dimethylpyridine 1-oxide of melting point 80°-83°.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. extractionthe residue is extracted with methylene chloride and saturated sodium chloride solution
  3. dry with materialThe methylene chloride phase is dried
  4. customevaporated
  5. customThe residue, crystallized from methylene chloride/ ether

출처 및 근거

ORD 기록
ord-3bf28547df6047c298170f041a6da9a4
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766133

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