Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 6-(p-Chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 6-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one | HCID 676750 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 6-(p-Chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one | HCID 677107 | 81.4% |
반응 단계
30.2 g (0.16 mole) of 6-(p-aminophenyl)-4,5-dihydropyridaz-3-one, 18.1 g (0.16 mole) of chloroacetyl chloride and 150 ml of absolute benzene are refluxed for 2 hours. The product is filtered off at room temperature, washed first with benzene and then with water, and dried under reduced pressure at 80° C. 34.6 g (81% of theory) of 6-(p-chloroacetylaminophenyl)-4,5-dihydropyridaz-3-one are obtained as a beige solid which, after recrystallization from dimethylformamide/water, melts, with decomposition, at 233° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04376771 |
| 출처 데이터셋 | uspto-grants-1983_03 |
| ORD ID | ord-13c388ee19f04ac3b777292122a83c54 |
| 출처 메모 | uspto-grants-1983_03 |